Harmonisation of the micronucleus assay in human buccal cells--a Human Micronucleus (HUMN) project (www.humn.org) initiative commencing in 2007.
نویسندگان
چکیده
Michael Fenech*, Claudia Bolognesi, Micheline Kirsch-Volders, Stefano Bonassi, Errol Zeiger, Siegfried Knasmüller and Nina Holland CSIRO Human Nutrition, Adelaide, Australia, Unit of Environmental Carcinogenesis, National Cancer Research Institute, Genoa, Italy, Laboratory for Cell Genetics, Vrije Universiteit Brussel, Brussel, Belgium, Unit of Molecular Epidemiology, National Cancer Research Institute, Genoa, Italy, Errol Zeiger Consulting, Chapel Hill, NC, USA, Institute of Cancer Research, Medical University, Vienna, Austria and School of Public Health, University of California, Berkeley, CA, USA
منابع مشابه
The micronucleus assay in human buccal cells as a tool for biomonitoring DNA damage: the HUMN project perspective on current status and knowledge gaps.
The micronucleus (MN) assay in exfoliated buccal cells is a useful and minimally invasive method for monitoring genetic damage in humans. This overview has concluded that although MN assay in buccal cells has been used since the 1980s to demonstrate cytogenetic effects of environmental and occupational exposures, lifestyle factors, dietary deficiencies, and different diseases, important knowled...
متن کاملThe HUMN and HUMNxL international collaboration projects on human micronucleus assays in lymphocytes and buccal cells--past, present and future.
The International Human Micronucleus (HUMN) Project (www.humn.org) was founded in 1997 to coordinate worldwide research efforts aimed at using micronucleus (MN) assays to study DNA damage in human populations. The central aims were to (i) collect databases on baseline MN frequencies and associated methodological, demographic, genetic and exposure variables, (ii) determine those variables that a...
متن کاملReport on the buccal micronucleus assay workshop organized by the International Human Micronucleus (HUMN) project--Antalya, Turkey 2007.
This report describes the aims, discussion and outcomes of the first Human Micronucleus collaborative project workshop on the buccal micronucleus assay. It was agreed at the workshop that three activities should be initiated as soon as possible namely (i) a method for collection of databases, (ii) writing of a protocol based on the most commonly used and best validated procedures and (iii) an i...
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The study of DNA damage in exfoliated buccal cells is a minimally invasive method for monitoring populations for exposure to genotoxic agents. The presence of micronuclei (MN) and other nuclear anomalies within these cells has been shown to be associated with genetic defects in genome maintenance, accelerated ageing, genotoxic damage and some degenerative diseases. To identify important informa...
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Waterpipe Tobacco Smoke(WTS) is an unhealthy life style that may increase the risk of genotoxic responses and chronic diseases such as cancer. Micronucleus test is a successful and reliable method which is used for screening of genetotoxic responses of whole body and also for screening those people who had already exposed to genotoxic compounds. In this study, specific questionnaires were desig...
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ورودعنوان ژورنال:
- Mutagenesis
دوره 22 1 شماره
صفحات -
تاریخ انتشار 2007